Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2022 Apr 1;44(3):103-105.
doi: 10.1097/MPH.0000000000002308.

A Case Series of Kawasaki Disease in Children With Sickle Cell Disease

Alison S Towerman  1   2 , Patrick J Reich  3 , Monica L Hulbert  1
Affiliations

A Case Series of Kawasaki Disease in Children With Sickle Cell Disease

Alison S Towerman et al. J Pediatr Hematol Oncol. .

Abstract

Prompt recognition and treatment of presumed bacterial infection in febrile children with sickle cell disease is necessary due to splenic dysfunction and impaired immune response. However, fever may be a manifestation of a noninfectious process, and health care providers must consider alternative sources. We describe 2 cases of children with sickle cell disease and persistent fevers, ultimately diagnosed with Kawasaki disease. These cases provide examples of an acute febrile illness that could lead to serious consequences if differential diagnoses are not considered and treatment is delayed.

PubMed Disclaimer

Conflict of interest statement

The authors declare no conflict of interest.

References

    1. Booth C, Inusa B, Obaro SK. Infection in sickle cell disease: a review. Int J Infect Dis. 2010;14:e2–e12.
    1. Yawn BP, Buchanan GR, Afenyi-Annan AN, et al. Management of sickle cell disease: summary of the 2014 evidence-based report by expert panel members. J Am Med Assoc. 2014;312:1033–1048.
    1. National Heart, Lung, and Blood Institute. Evidence-based management of sickle cell disease: expert panel report, 2014. 2104. Available at: www.nhlbi.nih.gov/healthpro/guidelines/sickle-cell-disease-guidelines/ . Accessed November 12, 2018.
    1. Patel RM, Shulman ST. Kawasaki disease: a comprehensive review of treatment options. J Clin Pharm Ther. 2015;40:620–625.
    1. Son MBF, Newburger JW. Kawasaki disease. Pediatr Rev. 2013;34:151–162.