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Review
. 2021 Nov:157:63-67.
doi: 10.1016/j.ejca.2021.07.042. Epub 2021 Sep 4.

Unusual metastasis in BRCA mutated pancreatic cancer while on maintenance Olaparib: Two case reports and review of the literature

Irene Assaf  1 , Laura Mans  2 , Rita Sakr  3 , Gontran Verset  2 , Jean L Van Laethem  2
Affiliations
Review

Unusual metastasis in BRCA mutated pancreatic cancer while on maintenance Olaparib: Two case reports and review of the literature

Irene Assaf et al. Eur J Cancer. 2021 Nov.

Abstract

The most common metastatic sites of pancreatic cancer are the liver, lymph nodes, peritoneum and lung. Here we report two cases of BRCA mutated pancreatic cancer that developed unusual metastasis while treatment with maintenance Olaparib and leading to rapid death. We hereby review the literature and address the possibility of a different nature and tumour biology of BRCA mutated cancer treated with PARP inhibitors.

Keywords: BRCA mutation; Olaparib; Pancreatic cancer; Tumour biology; Unusual metastasis.

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Conflict of interest statement

Conflict of interest statement The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

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