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Comment
. 2021 Dec 1;204(11):1345-1347.
doi: 10.1164/rccm.202107-1697LE.

Olfactory Nasal Nitric Oxide Link in COVID-19: A Marker of Neurogenesis or Risk Factor for Chronic Rhinosinusitis?

Amit Jain  1
Affiliations
Comment

Olfactory Nasal Nitric Oxide Link in COVID-19: A Marker of Neurogenesis or Risk Factor for Chronic Rhinosinusitis?

Amit Jain. Am J Respir Crit Care Med. .
No abstract available

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Figures

Figure 1.
Figure 1.
(A and B) Schematic representation of the mechanisms of anosmia in coronavirus disease (COVID-19). (C) Mechanisms linking increase in nasal nitric oxide levels with neurogenesis and recovery of smell in COVID-19. 3-HK = 3-hyroxykynureneine; ACE2 = angiotensin converting enzyme 2; GBC = global basal cell; HBC = horizontal basal cell; IDO = indoleamine 2,3-dioxygenase; iNOS = inducible nitric oxide synthase; KA = kynurenic acid; LIF = leukemia inhibitory factor; NAD = nicotinamide adenine dinucleotide; NMDA-R = N-methyl d-aspartate; NO = nitric oxide; NOS = nitric oxide synthase; QA = quinolinic acid; SARS-CoV-2 = severe acute respiratory syndrome coronavirus 2; TNF-α = tumor necrosis factor α; XA = xanthurenic acid.
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