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Review
. 2021 Dec 5:225:113818.
doi: 10.1016/j.ejmech.2021.113818. Epub 2021 Sep 3.

Cathepsin C inhibitors as anti-inflammatory drug discovery: Challenges and opportunities

Xiao Bao Shen  1 , Xing Chen  2 , Zhao Yan Zhang  2 , Fu Fang Wu  3 , Xin Hua Liu  4
Affiliations
Review

Cathepsin C inhibitors as anti-inflammatory drug discovery: Challenges and opportunities

Xiao Bao Shen et al. Eur J Med Chem. .

Abstract

Cathepsin C, an important lysosomal cysteine protease, mediates the maturation process of neutrophil serine proteases, and participates in the inflammation and immune regulation process associated with polymorphonuclear neutrophils. Therefore, cathepsin C is considered to be an attractive target for treating inflammatory diseases. With INS1007 (trade name: brensocatib) being granted a breakthrough drug designation by FDA for the treatment of Adult Non-cystic Fibrosis Bronchiectasis and Coronavirus Disease 2019, the development of cathepsin C inhibitor will attract attentions from medicinal chemists in the future soon. Here, we summarized the research results of cathepsin C as a therapeutic target, focusing on the development of cathepsin C inhibitor, and provided guidance and reference opinions for the upcoming development boom of cathepsin C inhibitor.

Keywords: Cat C inhibitor; Cathepsin C; Inflammatory disease; Therapeutic target.

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Conflict of interest statement

Declaration of competing interest All authors have contributed to the work, have read the manuscript and have agreed to be listed as authors. The submitted manuscript has not been published elsewhere and nor is it currently under review by another publication. No potential conflict of interest relevant to this article.

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