Advance in circular RNA modulation effects of heart failure

Abstract

CircRNA (circular RNA) is a kind of closed circular structure of noncoding RNA molecules without 5' hat structure and 3' polyA, mainly located in the cytoplasm or stored in exosomes. It is not affected by RNA exonuclease, so it's stable and hard to be degraded. Proved to be widespread in a variety of eukaryotes, most circRNAs are cyclized by exons, some are lasso structures formed by intron cyclization. Recently, circRNAs have been demonstrated to play crucial roles in cardiomyocyte hypertrophy, fibrosis, autophagy and apoptosis, participating in the development of heart failure. There is increasing evidence that circRNAs may be a novel target for the treatment of heart failure.

Keywords: Apoptosis; Autophagy; Cardiomyocyte fibrosis; Cardiomyocyte hypertrophy; Circular RNA; Heart failure.