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Review
. 2020 Dec:763S:100036.
doi: 10.1016/j.gene.2020.100036. Epub 2020 Jul 24.

Advance in circular RNA modulation effects of heart failure

Li Jiang  1 , Xiaoyan Wang  2 , Xiaopeng Zhan  1 , Sheng Kang  1 , Haibo Liu  3 , Yu Luo  4 , Li Lin  5
Affiliations
Free article
Review

Advance in circular RNA modulation effects of heart failure

Li Jiang et al. Gene. 2020 Dec.
Free article

Abstract

CircRNA (circular RNA) is a kind of closed circular structure of noncoding RNA molecules without 5' hat structure and 3' polyA, mainly located in the cytoplasm or stored in exosomes. It is not affected by RNA exonuclease, so it's stable and hard to be degraded. Proved to be widespread in a variety of eukaryotes, most circRNAs are cyclized by exons, some are lasso structures formed by intron cyclization. Recently, circRNAs have been demonstrated to play crucial roles in cardiomyocyte hypertrophy, fibrosis, autophagy and apoptosis, participating in the development of heart failure. There is increasing evidence that circRNAs may be a novel target for the treatment of heart failure.

Keywords: Apoptosis; Autophagy; Cardiomyocyte fibrosis; Cardiomyocyte hypertrophy; Circular RNA; Heart failure.

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Conflict of interest statement

Declaration of competing interest We declare that we have no financial and personal relationships with other people or organizations that can inappropriately influence our work, there is no professional or other personal interest of any nature or kind in any product, service and/or company that could be construed as influencing the position presented in, or the review of, the manuscript entitled.

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