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Review
. 2021 Sep 8;6(1):31.
doi: 10.1186/s41181-021-00146-9.

Highlight selection of radiochemistry and radiopharmacy developments by editorial board

Francisco Alves  1 , Inês F Antunes  2 , Emiliano Cazzola  3 , Frederik Cleeren  4 , Bart Cornelissen  2 , Antonia Denkova  5 , Jonathan Engle  6 , Alain Faivre-Chauvet  7 , Nic Gillings  8 , Jeroen J M A Hendrikx  9 , Amir R Jalilian  10 , Nicholas P van der Meulen  11 , Renata Mikolajczak  12 , Oliver C Neels  13 , Maroor R A Pillai  14 , Raymond Reilly  15 , Sietske Rubow  16 , Yann Seimbille  17 , Sarah Spreckelmeyer  18 , Wiktor Szymanski  19 , Carlotta Taddei  20
Affiliations
Review

Highlight selection of radiochemistry and radiopharmacy developments by editorial board

Francisco Alves et al. EJNMMI Radiopharm Chem. .

Abstract

Background: The Editorial Board of EJNMMI Radiopharmacy and Chemistry releases a biyearly highlight commentary to update the readership on trends in the field of radiopharmaceutical development.

Results: This commentary of highlights has resulted in 21 different topics selected by each member of the Editorial Board addressing a variety of aspects ranging from novel radiochemistry to first in man application of novel radiopharmaceuticals. Also the first contribution in relation to MRI-agents is included.

Conclusions: Trends in (radio)chemistry and radiopharmacy are highlighted demonstrating the progress in the research field being the scope of EJNMMI Radiopharmacy and Chemistry.

Keywords: Highlight selection; Radiochemistry; Radiopharmacy.

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Conflict of interest statement

The authors declare that they have no competing interest.

Figures

Fig. 1
Fig. 1
Photoswitchable MRI CA; A The thermally stable trans isomer can be switched to the metastable cis isomer, which will return to the initial form in a first order thermal process (on the timescale of seconds-minutes, depending on the temperature). B Temperature map in an NMR tube; polyethyleneimine silica beads coated with the NIR dye indocyanine green (ICG) that were warmed by infrared irradiation to act as a temperature source. (Reproduced with permission from ref. Wellm et al. (2021) under the terms of the Creative Commons Attribution-Non-Commercial License)
Fig. 2
Fig. 2
Overview of the automated synthesis cassette for radiolabelling of PSMA-11. This figure was obtained from Thisgaard et al. (2021) which was licensed under a Creative Commons License http://creativecommons.org/licences/by/4.0/
Fig. 3
Fig. 3
Schematic overview of convential IgG-radioimmunotherapy (IgG-RIT) and 2-step IgG-pretargeted radioimmunotherapy (IgG-PRIT), compared to self assembling and disassembling pretargeted radioimmunotherapy (SADA-PRIT). Each P53-SADA-BsAb monomer consists out of three domains: an antitumor domain (orange), an anti-DOTA domain (blue), and a SADA domain (green). Self-assembled tetramers disassemble into monomers that are rapidly cleared from circulation
Fig. 4
Fig. 4
The rapid and high-yield syntheses of unsymmetrical acyclic [11C]ureas under mild conditions (room temperature and within 7 min) using no-carrier-added [11C]carbonyl difluoride with aliphatic and aryl amines are described. This new methodology is compatible with a range of functional groups and with both aliphatic amines and anilines
See this image and copyright information in PMC

References

    1. Alnahwi AH, Tremblay S, Ait-Mohand S, Beaudoin JF, Guérin B. Automated radiosynthesis of 68Ga for large-scale routine production using 68Zn pressed target. Appl Radiat Isot. 2019;156:109014. doi: 10.1016/j.apradiso.2019.109014. - DOI - PubMed
    1. Aghevlian S, Cai Z, Hedley D, Winnik MA, Reilly RM. Radioimmunotherapy of PANC-1 human pancreatic cancer xenografts in NOD/SCID or NRG mice with Panitumumab labeled with Auger electron emitting, 111In or β-particle emitting, 177Lu. EJNMMI Radiopharm Chem. 2020;5:22. doi: 10.1186/s41181-020-00111-y. - DOI - PMC - PubMed
    1. Antunes IF, Franssen GM, Zijlma R, Laverman P, Boersma HH, Elsinga PH. New sensitive method for HEPES quantification in 68Ga-radiopharmaceuticals. EJNMMI Radiopharm Chem. 2020;5:1. doi: 10.1186/s41181-020-00093-x. - DOI - PMC - PubMed
    1. Carney B, Kossatz S, Reiner T. Molecular imaging of PARP. J Nucl Med. 2017;58:1025–30. doi: 10.2967/jnumed.117.189936. - DOI - PMC - PubMed
    1. Chan CY, Tan KV, Cornelissen B. PARP inhibitors in cancer diagnosis and therapy. Clin Cancer Res. 2021;27:1585–94. doi: 10.1158/1078-0432.CCR-20-2766. - DOI - PubMed

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