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Review
. 2021 Sep 8;21(10):39.
doi: 10.1007/s11892-021-01413-4.

What the Jackson Heart Study Has Taught Us About Diabetes and Cardiovascular Disease in the African American Community: a 20-year Appreciation

Tennille Leak-Johnson  1   2 , Fengxia Yan  3   4 , Pamela Daniels  3
Affiliations
Review

What the Jackson Heart Study Has Taught Us About Diabetes and Cardiovascular Disease in the African American Community: a 20-year Appreciation

Tennille Leak-Johnson et al. Curr Diab Rep. .

Abstract

Purpose of review: The burden of cardiometabolic diseases such as cardiovascular disease (CVD) and type 2 diabetes (T2D) is pronounced among African Americans. Research has shown that behavioral, social, metabolic, psychosocial, and genetic risk factors of CVD and T2D are closely interwoven. Approximately 20 years ago, the Jackson Heart Study (JHS) was established to investigate this constellation of risk factors.

Recent findings: Findings from neighborhood studies emphasize the importance of social cohesion and physical environment in the context CVD and T2D risk. Socioeconomic status factors such as income and education were significant predictors for CVD and T2D. Behavioral studies indicate that modifiable risk factors such as smoking, physical inactivity, lack of sleep, and poor nutrition are associated with CVD risk and all-cause mortality. Mental health also was found to be associated with CVD and T2D. Genetic influences are associated with disease etiology. This review summarizes the joint contributions of CVD and cardiometabolic risk factors in an African American population.

Keywords: African Americans; Cardiovascular disease; Jackson Heart Study; Neighborhoods; Risk factors; Type 2 diabetes.

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References

Papers of particular interest, published recently, have been highlighted as: • Of importance
    1. Barber S, Hickson DA, Wang X, Sims M, Nelson C, Diez-Roux AV. Neighborhood disadvantage, poor social conditions, and cardiovascular disease incidence among African American adults in the Jackson Heart Study. Am J Public Health. 2016;106(12):2219–26. https://doi.org/10.2105/AJPH.2016.303471 . - DOI - PubMed - PMC
    1. Barnett AH, Spiliopoulos AJ, Pyke DA, Stubbs WA, Burrin J, Alberti KG. Metabolic studies in unaffected co-twins of non-insulin-dependent diabetics. Br Med J (Clin Res Ed). 1981;282(6277):1656–8. https://doi.org/10.1136/bmj.282.6277.1656 . - DOI
    1. Cardel MI, Min YI, Sims M, Musani SK, Dulin-Keita A, DeBoer MD, et al. Association of psychosocial stressors with metabolic syndrome severity among African Americans in the Jackson Heart Study. Psychoneuroendocrinology. 2018;90:141–7. https://doi.org/10.1016/j.psyneuen.2018.02.014 . - DOI - PubMed - PMC
    1. Clark CR, Ommerborn MJ, Hickson DA, Grooms KN, Sims M, Taylor HA, et al. Neighborhood disadvantage, neighborhood safety and cardiometabolic risk factors in African Americans: biosocial associations in the Jackson Heart study. PLoS ONE. 2013;8(5): e63254. https://doi.org/10.1371/journal.pone.0063254 . - DOI - PubMed - PMC
    1. Gebreab SY, Hickson DA, Sims M, Wyatt SB, Davis SK, Correa A, et al. Neighborhood social and physical environments and type 2 diabetes mellitus in African Americans: the Jackson Heart Study. Health Place. 2017;43:128–37. https://doi.org/10.1016/j.healthplace.2016.12.001 . - DOI - PubMed

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