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. 2022 Jan;111(1):157-162.
doi: 10.1111/apa.16099. Epub 2021 Sep 15.

An increased asthma risk continued until young adulthood after early-childhood hospitalisation for wheezing

Marja Ruotsalainen  1 , Paula Heikkilä  2 , Katri Backman  1 , Matti Korppi  2
Affiliations

An increased asthma risk continued until young adulthood after early-childhood hospitalisation for wheezing

Marja Ruotsalainen et al. Acta Paediatr. 2022 Jan.

Abstract

Aim: The aim of this cohort study was to evaluate doctor-diagnosed and self-reported asthma in young adults after early-childhood hospitalisation for wheezing.

Methods: In this prospective-controlled follow-up, questionnaires were sent to 95 subjects aged 24-28 years, who had been hospitalised for their first episodes of wheezing under 24 months of age. Fifty-eight cases and 100 controls returned the questionnaires.

Results: The risk of doctor-diagnosed asthma was 2.14-fold (95% confidence interval 0.61-7.41), and the risk of self-reported asthma 2.39-fold (1.14-4.99) in cases compared to controls. The increased risk of self-reported asthma remained as statistically significant in analyses adjusted for current smoking, overweight and allergic rhinitis. Study subjects presented with wheezing symptoms, use of bronchodilators and inhaled corticosteroids, and with seasonal symptoms presumptive for allergic rhinitis during the last 12 months, more often than controls. The identification of a respiratory syncytial virus or rhinovirus during hospitalisation in early childhood was not anymore associated with asthma risk in adulthood. As expected, previous asthma during early childhood was a strong risk factor for asthma in young adulthood.

Conclusion: In this controlled questionnaire study, early-childhood hospitalisation for lower respiratory infection with wheezing was an independently significant risk factor of asthma in young adults.

Keywords: adulthood asthma; bronchiolitis; early-life wheezing; prospective design; questionnaire study.

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References

REFERENCES

    1. Piippo-Savolainen E, Korppi M. Wheezy babies-wheezy adults? Review on long-term outcome until adulthood after early childhood wheezing. Acta Paediatr. 2008;97:5-11.
    1. Piippo-Savolainen E, Remes S, Kannisto S, Korhonen K, Korppi M. Asthma and lung function 20 years after wheezing in infancy: results from a prospective follow-up study. Arch Pediatr Adolesc Med. 2004;158:1070-1076.
    1. Goksör E, Åmark M, Alm B, Gustafsson PM, Wennergren G. Asthma symptoms in early childhood-what happens then? Acta Paediatr. 2006;95:471-478.
    1. Sigurs N, Aljassim F, Kjellman B, et al. Asthma and allergy patterns over 18 years after severe RSV bronchiolitis in the first year of life. Thorax. 2010;65:1045-1052.
    1. Ruotsalainen M, Hyvärinen MK, Piippo-Savolainen E, Korppi M. Adolescent asthma after rhinovirus and respiratory syncytial virus bronchiolitis. Pediatr Pulmonol. 2013;48:633-639.