Covid-19 Vaccine Effectiveness and the Test-Negative Design

Affiliations

¹ From the Department of Biostatistics and Bioinformatics, Rollins School of Public Health, Emory University, Atlanta (N.E.D.); the Department of Biostatistics, Brown University School of Public Health, Providence, RI (J.W.H.); and the Faculty of Pharmacy and the Department of Social and Preventive Medicine, University of Montreal, Montreal (M.E.S.).

Editorial

Natalie E Dean et al. N Engl J Med. 2021.

. 2021 Oct 7;385(15):1431-1433.

doi: 10.1056/NEJMe2113151. Epub 2021 Sep 8.

¹ From the Department of Biostatistics and Bioinformatics, Rollins School of Public Health, Emory University, Atlanta (N.E.D.); the Department of Biostatistics, Brown University School of Public Health, Providence, RI (J.W.H.); and the Faculty of Pharmacy and the Department of Social and Preventive Medicine, University of Montreal, Montreal (M.E.S.).

No abstract available

Comment on

Effectiveness of Covid-19 Vaccines in Ambulatory and Inpatient Care Settings.
Thompson MG, Stenehjem E, Grannis S, Ball SW, Naleway AL, Ong TC, DeSilva MB, Natarajan K, Bozio CH, Lewis N, Dascomb K, Dixon BE, Birch RJ, Irving SA, Rao S, Kharbanda E, Han J, Reynolds S, Goddard K, Grisel N, Fadel WF, Levy ME, Ferdinands J, Fireman B, Arndorfer J, Valvi NR, Rowley EA, Patel P, Zerbo O, Griggs EP, Porter RM, Demarco M, Blanton L, Steffens A, Zhuang Y, Olson N, Barron M, Shifflett P, Schrag SJ, Verani JR, Fry A, Gaglani M, Azziz-Baumgartner E, Klein NP. Thompson MG, et al. N Engl J Med. 2021 Oct 7;385(15):1355-1371. doi: 10.1056/NEJMoa2110362. Epub 2021 Sep 8. N Engl J Med. 2021. PMID: 34496194 Free PMC article.

1. Lipsitch M, Dean NE. Understanding COVID-19 vaccine efficacy. Science 2020;370:763-765. - PubMed
1. Evans SJW, Jewell NP. Vaccine effectiveness studies in the field. N Engl J Med 2021;385:650-651. - PMC - PubMed
1. Thompson MG, Stenehjem E, Grannis S, et al. Effectiveness of Covid-19 vaccines in ambulatory and inpatient care settings. N Engl J Med. DOI: 10.1056/NEJMoa2110362. - DOI - PMC - PubMed
1. Jackson ML, Nelson JC. The test-negative design for estimating influenza vaccine effectiveness. Vaccine 2013;31:2165-2168. - PubMed
1. Chua H, Feng S, Lewnard JA, et al. The use of test-negative controls to monitor vaccine effectiveness: a systematic review of methodology. Epidemiology 2020;31:43-64. - PMC - PubMed