Erythrocyte-derived mitochondria take to the lupus stage
- PMID: 34496229
- DOI: 10.1016/j.cmet.2021.08.008
Erythrocyte-derived mitochondria take to the lupus stage
Abstract
Mitochondria have emerged as critical players in immune homeostasis and disease. Recently in Cell, while characterizing the removal of mitochondria from red blood cells during human erythropoiesis, Caielli et al. highlight the interferon-inducing potential of erythrocyte-derived mitochondria in lupus.
Copyright © 2021 Elsevier Inc. All rights reserved.
Comment on
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Erythroid mitochondrial retention triggers myeloid-dependent type I interferon in human SLE.Cell. 2021 Aug 19;184(17):4464-4479.e19. doi: 10.1016/j.cell.2021.07.021. Epub 2021 Aug 11. Cell. 2021. PMID: 34384544 Free PMC article.
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