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Case Reports
. 2023 Jul;30(4):e18.
doi: 10.1136/ejhpharm-2021-002999. Epub 2021 Sep 8.

Sulperazon-induced acute reactive thrombocytopenia during treatment of systemic lupus erythematosus: a case report

Mengen Lv  1   2 , Qing Xu  3   2 , Xianfei Ye  3   2 , Qian Yu  3   2
Affiliations
Case Reports

Sulperazon-induced acute reactive thrombocytopenia during treatment of systemic lupus erythematosus: a case report

Mengen Lv et al. Eur J Hosp Pharm. 2023 Jul.

Abstract

The purpose of this study is to report a patient who developed acute reactive thrombocytopenia while undergoing treatment with sulperazon for systemic lupus erythematosus (SLE). Sulperazon is a broad-spectrum antibiotic that can act against a wide range of microorganisms, but rarely causes severe thrombocytopenic events. We describe a 62-year-old man with new-onset acute reactive thrombocytopenia who experienced a precipitous fall in the platelet count from 168×109/L to 1×109/L within 29 hours after exposure to sulperazon. Sulperazon was immediately discontinued followed by administration of intravenous immunoglobulin for six consecutive days. The platelet count eventually recovered and petechiae at the injection sites improved. No complications secondary to acute reactive thrombocytopenia were observed except petechiae.

Keywords: case reports; clinical medicine; drug monitoring; education; pharmacy; pharmacy administration.

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Conflict of interest statement

Competing interests: None declared.

Figures

Figure 1
Figure 1
Trajectory of the platelet count during the hospital stay.
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References

    1. Mohsen S, Dickinson JA, Somayaji R. Update on the adverse effects of antimicrobial therapies in community practice. Can Fam Physician 2020;66:651–9. - PMC - PubMed
    1. Xin X, Jian L, Xia X, et al. . A multicentre clinical study on the injection of ceftriaxone/sulbactam compared with cefoperazone/sulbactam in the treatment of respiratory and urinary tract infections. Ann Clin Microbiol Antimicrob 2013;12:38–8. 10.1186/1476-0711-12-38 - DOI - PMC - PubMed
    1. Bodey GP, Elting LS, Narro J, et al. . An open trial of cefoperazone plus sulbactam for the treatment of fever in cancer patients. J Antimicrob Chemother 1993;32:141–52. 10.1093/jac/32.1.141 - DOI - PubMed
    1. Suzuki K, Horiba M. [Laboratory and clinical study of sulbactam/cefoperazone (SBT/CPZ) on bacterial prostatitis]. Hinyokika Kiyo 1991;37:1333–43. - PubMed
    1. Zitella LJ. Approach to the hospitalized patient with thrombocytopenia. J Adv Pract Oncol 2021;12:267–70. 10.6004/jadpro.2021.12.3.9 - DOI - PMC - PubMed

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