Role of exercise in preventing and restoring gut dysbiosis in patients with inflammatory bowel diseases: A review

doi:10.3748/wjg.v27.i30.5037

Review

. 2021 Aug 14;27(30):5037-5046.

doi: 10.3748/wjg.v27.i30.5037.

Role of exercise in preventing and restoring gut dysbiosis in patients with inflammatory bowel diseases: A review

Tilemachos Koutouratsas¹, Anastassios Philippou², George Kolios³, Michael Koutsilieris², Maria Gazouli⁴

Affiliations

¹ Department of Basic Medical Sciences, Laboratory of Biology, Medical School, National and Kapodistrian University of Athens, Athens 11527, Greece.
² Department of Basic Medical Sciences, Laboratory of Physiology, School of Medicine, National and Kapodistrian University of Athens, Athens 11527, Greece.
³ Department of Medicine, Laboratory of Pharmacology, Democritus University of Thrace, Alexandroupolis 68100, Greece.
⁴ Department of Basic Medical Sciences, Laboratory of Biology, Medical School, National and Kapodistrian University of Athens, Athens 11527, Greece. mgazouli@med.uoa.gr.

PMID: 34497433
PMCID: PMC8384738
DOI: 10.3748/wjg.v27.i30.5037

Review

Role of exercise in preventing and restoring gut dysbiosis in patients with inflammatory bowel diseases: A review

Tilemachos Koutouratsas et al. World J Gastroenterol. 2021.

. 2021 Aug 14;27(30):5037-5046.

doi: 10.3748/wjg.v27.i30.5037.

Authors

Tilemachos Koutouratsas¹, Anastassios Philippou², George Kolios³, Michael Koutsilieris², Maria Gazouli⁴

Affiliations

¹ Department of Basic Medical Sciences, Laboratory of Biology, Medical School, National and Kapodistrian University of Athens, Athens 11527, Greece.
² Department of Basic Medical Sciences, Laboratory of Physiology, School of Medicine, National and Kapodistrian University of Athens, Athens 11527, Greece.
³ Department of Medicine, Laboratory of Pharmacology, Democritus University of Thrace, Alexandroupolis 68100, Greece.
⁴ Department of Basic Medical Sciences, Laboratory of Biology, Medical School, National and Kapodistrian University of Athens, Athens 11527, Greece. mgazouli@med.uoa.gr.

PMID: 34497433
PMCID: PMC8384738
DOI: 10.3748/wjg.v27.i30.5037

Abstract

Inflammatory bowel diseases (IBD) include a spectrum of chronic inflammatory disorders of the gastrointestinal tract whose pathogenesis is yet to be elucidated. The intestinal microbiome has been studied as a causal component, with certain microbiotic alterations having been observed in subtypes of IBD. Physical exercise is a modulator of the intestinal microbiome, causing shifts in its composition that are partially corrective of those observed in IBD; furthermore, physical exercise may be beneficial in patients with certain IBD subtypes. This review studies the effects of physical exercise on the human gut microbiome while investigating pathophysiologic mechanisms that could explain physical activity's clinical effects on patients with IBD.

Keywords: Crohn’s disease; Exercise; Inflammatory bowel disease; Microbiome; Pouchitis; Ulcerative colitis.

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Conflict of interest statement

Conflict-of-interest statement: Authors have nothing to disclose.

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References

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[1] Guan Q. A Comprehensive Review and Update on the Pathogenesis of Inflammatory Bowel Disease. J Immunol Res. 2019;2019:7247238. - PMC - PubMed

[2] Guan Q. A Comprehensive Review and Update on the Pathogenesis of Inflammatory Bowel Disease. J Immunol Res. 2019;2019:7247238. - PMC - PubMed

[3] Glassner KL, Abraham BP, Quigley EMM. The microbiome and inflammatory bowel disease. J Allergy Clin Immunol. 2020;145:16–27. - PubMed

[4] Glassner KL, Abraham BP, Quigley EMM. The microbiome and inflammatory bowel disease. J Allergy Clin Immunol. 2020;145:16–27. - PubMed

[5] Furey TS, Sethupathy P, Sheikh SZ. Redefining the IBDs using genome-scale molecular phenotyping. Nat Rev Gastroenterol Hepatol. 2019;16:296–311. - PMC - PubMed

[6] Furey TS, Sethupathy P, Sheikh SZ. Redefining the IBDs using genome-scale molecular phenotyping. Nat Rev Gastroenterol Hepatol. 2019;16:296–311. - PMC - PubMed

[7] Chen P, Zhou G, Lin J, Li L, Zeng Z, Chen M, Zhang S. Serum Biomarkers for Inflammatory Bowel Disease. Front Med (Lausanne) 2020;7:123. - PMC - PubMed

[8] Chen P, Zhou G, Lin J, Li L, Zeng Z, Chen M, Zhang S. Serum Biomarkers for Inflammatory Bowel Disease. Front Med (Lausanne) 2020;7:123. - PMC - PubMed

[9] Veltkamp C, Tonkonogy SL, De Jong YP, Albright C, Grenther WB, Balish E, Terhorst C, Sartor RB. Continuous stimulation by normal luminal bacteria is essential for the development and perpetuation of colitis in Tg(epsilon26) mice. Gastroenterology. 2001;120:900–913. - PubMed

[10] Veltkamp C, Tonkonogy SL, De Jong YP, Albright C, Grenther WB, Balish E, Terhorst C, Sartor RB. Continuous stimulation by normal luminal bacteria is essential for the development and perpetuation of colitis in Tg(epsilon26) mice. Gastroenterology. 2001;120:900–913. - PubMed

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Role of exercise in preventing and restoring gut dysbiosis in patients with inflammatory bowel diseases: A review

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Role of exercise in preventing and restoring gut dysbiosis in patients with inflammatory bowel diseases: A review

Authors

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