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Case Reports
. 2021 Jun 19;4(5):267-271.
doi: 10.1002/iju5.12298. eCollection 2021 Sep.

A case of adenocarcinoma of the rete testis with durable response to cisplatin-based chemotherapy

Shunsuke Owa  1 , Takeshi Sasaki  1 , Katsunori Uchida  2 , Susumu Watanabe  1 , Momoko Kato  1 , Yusuke Sugino  1 , Manabu Kato  1 , Satoru Masui  1 , Kouhei Nishikawa  1 , Yuko Yoshio  1 , Hideki Kanda  1 , Yoshiki Sugimura  1 , Takahiro Inoue  1
Affiliations
Case Reports

A case of adenocarcinoma of the rete testis with durable response to cisplatin-based chemotherapy

Shunsuke Owa et al. IJU Case Rep. .

Abstract

Introduction: Adenocarcinoma of the rete testis is a rare malignancy with a poor prognosis. We report a case of adenocarcinoma of the rete testis with a durable response to cisplatin-based chemotherapy.

Case presentation: A 48-year-old man with Down syndrome (trisomy 21) presented with a 1-month history of painless swelling of the left scrotum. The physical examination revealed a left testis with a hydrocele associated with a tumor and enlarged pelvic and para-aortic lymph nodes. He underwent a radical orchiectomy. The specimen was diagnosed as adenocarcinoma of the rete testis. The patient received 7 cycles of chemotherapy (1 cycle of BEP and 6 cycles of EP) postoperatively. The metastatic lymph nodes were reduced in size for at least 12 months. Our patient with adenocarcinoma of the rete testis obtained an acceptable response to cisplatin-based chemotherapy.

Conclusion: We treated a patient with an adenocarcinoma of the rete testis who had an acceptable response to platinum-based chemotherapy.

Keywords: adenocarcinoma of the rete testis; cisplatin‐based chemotherapy.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Fig. 1
Fig. 1
Ultrasonography showed testicular enlargement with a mosaic appearance inside the hydrocele of the testis, which was suspicious for a testicular tumor. CT showed a testicular tumor with a maximum diameter of 6.2 cm inside the hydrocele of the testis. Metastases were found in the pelvic and pararenal aorta lymph nodes, with a maximum diameter of 6.1 cm.
Fig. 2
Fig. 2
Macroscopic findings. A dark red tumor showing small hemorrhagic areas was observed within the resected specimen. The tumor measured 45 × 50 × 60 mm.
Fig. 3
Fig. 3
(a) Histologically, tumor cells with a high nuclear‐to‐cytoplasm ratio grew in a sheet‐like pattern and showed extensive necrosis (bar = 200 µm). (b) Small foci of proliferating spindle‐shaped tumor cells are seen. In situ lesions were recognized in the rete testis (arrows) (bar = 100 µm).
Fig. 4
Fig. 4
Clinical course of the case. Chemotherapy was administered after orchiectomy. After the end of chemotherapy, the lymph node metastases continued to shrink.
See this image and copyright information in PMC

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