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. 2022 Jun;36(12):3229-3233.
doi: 10.1080/14786419.2021.1956923. Epub 2021 Sep 9.

Chemical constituents of Impatiens chapaensis Tard. and their α-glucosidase inhibition activities

Nguyen Thi Thuy Linh  1   2 , Trinh Thi Thuy  1   2 , Nguyen Thanh Tam  2 , Ba Thi Cham  1   2 , Khieu Thi Tam  3 , Nguyen Hoang Sa  4 , Do Thi Thao  5 , Vu Tien Chinh  1   6 , Nguyen Thi Hoang Anh  1   2
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Chemical constituents of Impatiens chapaensis Tard. and their α-glucosidase inhibition activities

Nguyen Thi Thuy Linh et al. Nat Prod Res. 2022 Jun.

Abstract

Sixteen compounds (1-16) were isolated from Impatiens chapaensis. Chemical structures were determined by spectroscopic analyses and comparisons with previously published data. This report is the first to identify compounds 1, 5-7, 10, 12-14, and 16 from the genus Impatiens. Seven chosen isolates (5, 7, 10, 11, 12, 15, and 16) were submitted for α-glucosidase inhibition assays with acarbose as the positive control (IC50 = 227.14 ± 13.71 µM). Flavonoid 5 exhibited a significant inhibitory effect (IC50 = 101.00 ± 9.01 µM).

Keywords: Balsaminaceae; Impatiens chapaensis; flavonoid glycoside; neolignan glycoside; sesquiterpene.

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