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. 2021 Dec;27(12):3180-3182.
doi: 10.3201/eid2712.211792. Epub 2021 Sep 9.

Breakthrough Infections of E484K-Harboring SARS-CoV-2 Delta Variant, Lombardy, Italy

Andreina Baj, Federica Novazzi, Renee Pasciuta, Angelo Genoni, Francesca Drago Ferrante, Marilena Valli, Michele Partenope, Rosalia Tripiciano, Andrea Ciserchia, Giuseppe Catanoso, Daniele Focosi, Fabrizio Maggi

Breakthrough Infections of E484K-Harboring SARS-CoV-2 Delta Variant, Lombardy, Italy

Andreina Baj et al. Emerg Infect Dis. 2021 Dec.

Abstract

The Delta variant of concern of severe acute respiratory syndrome coronavirus 2 is dominant worldwide. We report a case cluster caused by Delta sublineage B.1.617.2 harboring the mutation E484K in Italy during July 11-July 29, 2021. This mutation appears to affect immune response and vaccine efficacy; monitoring its appearance is urgent.

Keywords: B.1.617.2; COVID-19; E484K; Italy; SARS-CoV-2; coronavirus disease; delta variant; mutation of concern; respiratory infections; severe acute respiratory syndrome coronavirus 2; variant of concern; viruses; zoonoses.

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