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Comment
. 2021 Dec 23;138(25):2731-2733.
doi: 10.1182/blood.2021012641.

BACH2 is a putative T-cell lymphoma tumor suppressor that may play a role in product-derived CAR T-cell lymphomas

Jay Daniels  1   2 , Jaehyuk Choi  1   2   3
Affiliations
Comment

BACH2 is a putative T-cell lymphoma tumor suppressor that may play a role in product-derived CAR T-cell lymphomas

Jay Daniels et al. Blood. .
No abstract available

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Figures

Figure 1.
Figure 1.
Mutation pattern consistent with a tumor suppressor role in BACH2. Alterations in the BACH2 gene locus in patients with CAR T-cell lymphomas (Micklethwaite et al1) and in CTCL (Park et al2). Black rectangles represent BACH2 exons. Coordinates shown use the hg19 genome build. SNV, single nucleotide variant; TSS, transcriptional start site.
See this image and copyright information in PMC

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References

    1. Micklethwaite KP, Gowrishankar K, Gloss BS, et al. Investigation of product-derived lymphoma following infusion of piggyBac-modified CD19 chimeric antigen receptor T cells. Blood. 2021;138(16):1391-1405. - PMC - PubMed
    1. Park J, Daniels J, Wartewig T, et al. Integrated genomic analyses of cutaneous T cell lymphomas reveal the molecular bases for disease heterogeneity. Blood. 2021;138(14):1225-1236. - PMC - PubMed
    1. Choi J, Goh G, Walradt T, et al. Genomic landscape of cutaneous T cell lymphoma. Nat Genet. 2015;47(9):1011-1019. - PMC - PubMed
    1. Daniels J, Doukas PG, Escala MEM, et al. Cellular origins and genetic landscape of cutaneous gamma delta T cell lymphomas. Nat Commun. 2020;11(1):1806. - PMC - PubMed
    1. Wang J, Mullighan CG, Easton J, et al. CREST maps somatic structural variation in cancer genomes with base-pair resolution. Nat Methods. 2011;8(8):652-654. - PMC - PubMed

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