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Review
. 2021 Oct 16;398(10309):1450-1460.
doi: 10.1016/S0140-6736(21)01826-2. Epub 2021 Sep 6.

Treatment of fibrotic interstitial lung disease: current approaches and future directions

Kerri A Johannson  1 , Nazia Chaudhuri  2 , Ayodeji Adegunsoye  3 , Paul J Wolters  4
Affiliations
Free article
Review

Treatment of fibrotic interstitial lung disease: current approaches and future directions

Kerri A Johannson et al. Lancet. .
Free article

Abstract

Fibrotic interstitial lung disease (ILD) represents a large group of pulmonary disorders that are often progressive and associated with high morbidity and early mortality. Important advancements in the past 10 years have enabled a better understanding, characterisation, and treatment of these diseases. This Series paper summarises the current approach to treatment of fibrotic ILDs, both pharmacological and non-pharmacological, including recent discoveries and practice-changing clinical trials. We further outline controversies and challenges, with discussion of evolving concepts and future research directions.

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Conflict of interest statement

Declaration of interests KAJ reports grants from the Chest Foundation, Three Lakes Foundation, University Health Foundation, and the University of Calgary Cumming School of Medicine, and consultancy fees from Boehringer-Ingelheim, Blade Therapeutics, Theravance, Pliant Therapeutics, Hoffman-La Roche, and Three Lakes Foundation, outside the submitted work. NC reports grants from Boehringer-Ingelheim, consulting fees from Boehringer-Ingelheim and Roche, and educational support from Boehringer-Ingelheim and Roche, outside the submitted work. AA reports grants from the US National Institutes of Health (NIH), consultancy fees from Boehringer-Ingelheim and Genentech, and personal fees from Boehringer-Ingelheim, outside the submitted work. PJW reports grants from NIH, Boehringer-Ingelheim, Roche, Sanofi, and Pliant Therapeutics, and consulting fees from Blade Therapeutics and Gossamer Bio, outside the submitted work.

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