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Review
. 2021 Sep 2;26(17):5325.
doi: 10.3390/molecules26175325.

Chemo-Preventive Action of Resveratrol: Suppression of p53-A Molecular Targeting Approach

Rokeya Akter  1   2 , Md Habibur Rahman  2   3 , Deepak Kaushik  4 , Vineet Mittal  4 , Diana Uivarosan  5 , Aurelia Cristina Nechifor  6 , Tapan Behl  7 , Chenmala Karthika  8 , Manuela Stoicescu  9 , Mihai Alexandru Munteanu  9 , Cristiana Bustea  9 , Simona Bungau  10   11
Affiliations
Review

Chemo-Preventive Action of Resveratrol: Suppression of p53-A Molecular Targeting Approach

Rokeya Akter et al. Molecules. .

Abstract

Extensive experimental, clinical, and epidemiological evidence has explained and proven that products of natural origin are significantly important in preventing and/or ameliorating various disorders, including different types of cancer that researchers are extremely focused on. Among these studies on natural active substances, one can distinguish the emphasis on resveratrol and its properties, especially the potential anticancer role. Resveratrol is a natural product proven for its therapeutic activity, with remarkable anti-inflammatory properties. Various other benefits/actions have also been reported, such as cardioprotective, anti-ageing, antioxidant, etc. and its rapid digestion/absorption as well. This review aims to collect and present the latest published studies on resveratrol and its impact on cancer prevention, molecular signals (especially p53 protein participation), and its therapeutic prospects. The most recent information regarding the healing action of resveratrol is presented and concentrated to create an updated database focused on this topic presented above.

Keywords: cancer prevention; cardio protection; clinical trials; molecular signals; natural compound; p53; polyphenol; red wine; resveratrol.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
PRISMA flow-chart describing the process of selection the references.
Figure 2
Figure 2
The contribution of p53 in the effects of resveratrol in cancer cells. MAP kinase, mitogen activated protein kinase; WTp53, wild type p53.
Figure 3
Figure 3
Potential anti-tumor effects of resveratrol. SASP, senescence-associated secretory phenotype; DLC1, deleted in liver cancer1; and ROS, reactive oxygen species.
Figure 4
Figure 4
The preventive effect of resveratrol on human health in vitro, in vivo, and clinical evidence.
See this image and copyright information in PMC

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MeSH terms

Substances