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. 2021 Aug 24;10(17):3768.
doi: 10.3390/jcm10173768.

Sex Differences in the Clinical Features and Outcomes of Patients with Acute Coronary Syndrome Treated with Two Generations (Absorb and Magmaris) of Bioresorbable Vascular Scaffolds

Adrian Włodarczak  1 , Piotr Rola  2 , Marek Szudrowicz  1 , Magdalena Łanocha  3 , Mateusz Barycki  2 , Jan Jakub Kulczycki  1 , Alicja Gosiewska  4 , Karol Turkiewicz  1 , Maciej Lesiak  5 , Adrian Doroszko  6
Affiliations

Sex Differences in the Clinical Features and Outcomes of Patients with Acute Coronary Syndrome Treated with Two Generations (Absorb and Magmaris) of Bioresorbable Vascular Scaffolds

Adrian Włodarczak et al. J Clin Med. .

Abstract

Background: Despite the developments in percutaneous coronary interventions (PCI), women are still more likely than men to have unfavorable outcomes after PCI performed in Acute Coronary Syndrome (ACS). The mechanisms of this phenomena are not fully understood. Potential benefits of bioresorbable scaffolds (BRS) may be particularly expressed in the female population. Nevertheless, the data available currently are inconsistent and limited. This study evaluated the gender-related differences in the short-term clinical outcomes in ACS patients treated with implantation of two generations of BRS (first generation, Absorb; second generation, Magmaris).

Methods: The study was divided into two arms. To the first one, we qualified 160 patients with ACS treated with PCI who received 210 Absorb scaffolds. The second arm was composed of 193 patients with ACS who underwent PCI with Magmaris implantation.

Results: There were no significant sex-related differences in primary endpoints (cardiovascular-death, myocardial infarction, in-stent thrombosis) or principal secondary endpoints (of target-lesion failure, scaffold restenosis, death from any reason, other cardiovascular events) in either generation of BRS in a 1-year follow-up.

Conclusions: Both genders tended to have a similar outcome in routine clinical practice following BRS implantation due to ACS. The magnesium bioresorbable scaffold (Magmaris) early outcome seemed to be more favorable in comparison to the Absorb scaffold.

Keywords: Absorb; Magmaris; acute coronary syndrome (ACS); bioresorbable scaffold (BRS); coronary artery disease (CAD); gender-related prognosis; percutaneous coronary intervention (PCI); sex differences.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Study inclusion and exclusion criteria. PCI, percutaneous coronary intervention; BRS, bioresorbable scaffolds; ACS, acute coronary syndrome; STEMI, ST-segment elevation myocardial infarct; CABG, coronary artery bypass graft. * Left main disease or equivalent, three-vessel disease, or multi-vessel disease disqualification from CABG by local Heart Team.
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