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. 2021 Aug 25;10(17):3810.
doi: 10.3390/jcm10173810.

Oocyte Vitrification for Fertility Preservation in Women with Benign Gynecologic Disease: French Clinical Practice Guidelines Developed by a Modified Delphi Consensus Process

Blandine Courbiere  1   2 , Enora Le Roux  3   4 , Emmanuelle Mathieu d'Argent  5 , Antoine Torre  6 , Catherine Patrat  7 , Christophe Poncelet  8   9 , Jacques Montagut  10 , Anne-Sophie Gremeau  11 , Hélène Creux  12 , Maëliss Peigné  9   13 , Isabella Chanavaz-Lacheray  14 , Lara Dirian  15 , Xavier Fritel  16   17 , Jean-Luc Pouly  18 , Arnaud Fauconnier  19   20 , On Behalf Of The PreFerBe Expert Panel
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Oocyte Vitrification for Fertility Preservation in Women with Benign Gynecologic Disease: French Clinical Practice Guidelines Developed by a Modified Delphi Consensus Process

Blandine Courbiere et al. J Clin Med. .

Abstract

International guidelines are published to provide standardized information and fertility preservation (FP) care for adults and children. The purpose of the study was to conduct a modified Delphi process for generating FP guidelines for BGD. A steering committee identified 42 potential FP practices for BGD. Then 114 key stakeholders were asked to participate in a modified Delphi process via two online survey rounds and a final meeting. Consensus was reached for 28 items. Among them, stakeholders rated age-specific information concerning the risk of diminished ovarian reserve after surgery as important but rejected proposals setting various upper and lower age limits for FP. All women should be informed about the benefit/risk balance of oocyte vitrification-in particular about the likelihood of live birth according to age. FP should not be offered in rASRM stages I and II endometriosis without endometriomas. These guidelines could be useful for gynecologists to identify situations at risk of infertility and to better inform women with BGDs who might need personalized counseling for FP.

Keywords: benign gynecologic disease; consensus study; fertility preservation; modified Delphi method; oocyte vitrification.

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Conflict of interest statement

The authors declare no conflict of interest that may be perceived as inappropriately influencing the representation or interpretation of reported research results. The funders had no role in the design of the study; in the collection, analyses, or interpretation of data; in the writing of the manuscript; or in the decision to publish the results.

Figures

Figure 1
Figure 1
A stepwise two-round modified Delphi consensus survey to approve clinical guideline for fertility preservation in women with benign gynecologic disease.
See this image and copyright information in PMC

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