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Review
. 2021 Aug 28;10(17):3867.
doi: 10.3390/jcm10173867.

New Indications for Liver Transplantation

Alberto Zanetto  1 , Sarah Shalaby  1 , Martina Gambato  1 , Giacomo Germani  1 , Marco Senzolo  1 , Debora Bizzaro  1 , Francesco Paolo Russo  1 , Patrizia Burra  1
Affiliations
Review

New Indications for Liver Transplantation

Alberto Zanetto et al. J Clin Med. .

Abstract

Liver transplantation (LT) is an important therapeutic option for the treatment of several liver diseases. Modern LT is characterized by remarkable improvements in post-transplant patient survival, graft survival, and quality of life. Thanks to these great improvements, indications for LT are expanding. Nowadays, clinical conditions historically considered exclusion criteria for LT, have been considered new indications for LT, showing survival advantages for patients. In this review, we provide an updated overview of the principal newer indications for LT, with particular attention to alcoholic hepatitis, acute-on-chronic liver failure (ACLF), cholangiocarcinoma and colorectal cancer metastases.

Keywords: acute-on-chronic liver failure; alcoholic hepatitis; cholangiocarcinoma; colorectal cancer metastases.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
New indications for liver transplantation. Controversial indications include severe alcoholic hepatitis and ACLF grade 3. Questionable indications include non-hepatocellular carcinoma liver cancer, and liver metastases from colorectal cancer. CCA: cholangiocarcinoma; ACLF: acute-on-chronic liver failure.
See this image and copyright information in PMC

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