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. 2021 Aug 28;18(17):9076.
doi: 10.3390/ijerph18179076.

Incidence and Prevalence Analysis of Non-Small-Cell and Small-Cell Lung Cancer Using Administrative Data

Andrea Ricotti  1 , Veronica Sciannameo  2 , William Balzi  3 , Andrea Roncadori  3 , Paola Canavese  4 , Arianna Avitabile  4 , Ilaria Massa  3 , Paola Berchialla  5
Affiliations

Incidence and Prevalence Analysis of Non-Small-Cell and Small-Cell Lung Cancer Using Administrative Data

Andrea Ricotti et al. Int J Environ Res Public Health. .

Abstract

Treatment of lung cancer depends on the stage of the tumor and the histological type. In recent years, the histological confirmation of lung non-small-cell lung cancer has become crucial since the availability of selective target therapeutic approaches. The aim of the study was to develop a validated procedure to estimate the incidence and prevalence of non-small-cell and small-cell lung cancer from healthcare administrative data. A latent class model for categorical variables was applied. The following observed variables were included in the analysis: ICD-9-CM codes in the Hospital Discharge Registry, ATC codes of medications dispensed present in the Drugs Prescriptions Registry, and the procedure codes in the Outpatient Registry. The proportion of non-small-cell lung cancer diagnoses was estimated to be 85% of the total number of lung cancer on the cohort of incident cases and 89% on the cohort of prevalent cases. External validation on a cohort of 107 patients with a lung cancer diagnosis and histological confirmation showed a sensitivity of 95.6% (95%CI: 89-98.8%) and specificity of 94.1% (95%CI: 71.3-99.9%). The procedure is an easy-to-use tool to design subpopulation-based studies on lung cancer and to better plan resource allocation, which is important since the introduction of new targeted therapies in non-small-cell lung carcinoma.

Keywords: incidence; non-small-cell lung cancer; small-cell lung cancer.

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Conflict of interest statement

A.A. and P.C. are employees of Roche S.p.A., Monza, Italy. The sponsor had no role in the design, execution, interpretation, or writing of the study.

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