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Review
. 2021 Aug 27;22(17):9274.
doi: 10.3390/ijms22179274.

Molecular Basis of Endometriosis and Endometrial Cancer: Current Knowledge and Future Perspectives

Milan Terzic  1   2   3 , Gulzhanat Aimagambetova  4 , Jeannette Kunz  4 , Gauri Bapayeva  2 , Botagoz Aitbayeva  2 , Sanja Terzic  1 , Antonio Simone Laganà  5
Affiliations
Review

Molecular Basis of Endometriosis and Endometrial Cancer: Current Knowledge and Future Perspectives

Milan Terzic et al. Int J Mol Sci. .

Abstract

The human endometrium is a unique tissue undergoing important changes through the menstrual cycle. Under the exposure of different risk factors in a woman's lifetime, normal endometrial tissue can give rise to multiple pathologic conditions, including endometriosis and endometrial cancer. Etiology and pathophysiologic changes behind such conditions remain largely unclear. This review summarizes the current knowledge of the pathophysiology of endometriosis and its potential role in the development of endometrial cancer from a molecular perspective. A better understanding of the molecular basis of endometriosis and its role in the development of endometrial pathology will improve the approach to clinical management.

Keywords: endometrial cancer; endometriosis; molecular basis of endometriosis; ovarian cancer.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Risk factors for endometriosis and endometrial cancer. Created at BioRender.com (accessed on 15 July 2021).
See this image and copyright information in PMC

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