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Review
. 2021 Oct;48(4):631-642.
doi: 10.1016/j.cps.2021.05.007. Epub 2021 Jun 27.

Non-Operative Options for Loco-regional Melanoma

Rebecca Knackstedt  1 , Timothy Smile  2 , Jennifer Yu  2 , Brian R Gastman  3
Affiliations
Review

Non-Operative Options for Loco-regional Melanoma

Rebecca Knackstedt et al. Clin Plast Surg. 2021 Oct.

Abstract

Malignant melanoma is the 5th most common cancer and stage IV melanoma accounts for approximately 4% of new melanoma diagnoses in the United States. The prognosis for regionally advanced disease is poor, but there have been numerous recent advances in the medical management of melanoma in-transit metastases. The goal of this paper is to review currently accepted treatment options for in-transit metastases and introduce emerging therapies. Therapies to be discussed include limb perfusion and infusion, immunotherapy, checkpoint inhibitors, and radiation therapy.

Keywords: Checkpoint inhibitors; Immunotherapy; Injectable therapy; Melanoma; Radiation therapy.

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