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. 2021 Sep 9;6(1):53.
doi: 10.1038/s41536-021-00161-z.

Further validation of the efficacy of mesenchymal stem cell infusions for reducing mortality in COVID-19 patients with ARDS

Ashok K Shetty  1 , Padmashri A Shetty  2 , Gabriele Zanirati  3 , Kunlin Jin  4
Affiliations

Further validation of the efficacy of mesenchymal stem cell infusions for reducing mortality in COVID-19 patients with ARDS

Ashok K Shetty et al. NPJ Regen Med. .

Abstract

Recent double-blind, randomized, controlled trials reported that human umbilical cord-derived mesenchymal stem cell (MSC) infusions in COVID-19 patients with acute respiratory distress syndrome (ARDS) could diminish cytokine storm and lung damage. While these outcomes are significant, additional phase II/III trials are required to validate the efficacy of MSCs to improve the survival of COVID-19 patients with ARDS. Future studies also need to assess the efficacy of MSCs to prevent long COVID.

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Conflict of interest statement

The authors declare no competing interests.

Figures

Fig. 1
Fig. 1. Potential mechanisms by which mesenchymal stem cells (MSCs) can improve outcomes in COVID-19 patients.
MSCs can directly modulate a variety of immune cells from their proinflammatory states into non-inflammatory or anti-inflammatory phenotypes, suppress cytokine storm, and promote lung regeneration.
See this image and copyright information in PMC

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