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Review
. 2021 Aug 24:12:725829.
doi: 10.3389/fendo.2021.725829. eCollection 2021.

Thyroid Dysfunction and Sleep Disorders

Affiliations
Review

Thyroid Dysfunction and Sleep Disorders

Max E Green et al. Front Endocrinol (Lausanne). .

Abstract

Thyroid disorders and sleep disorders are common problems in the general population that can affect people of all ages, backgrounds, and sexes, but little is known about their clinical associations. We reviewed the literature assessing the associations between thyroid disease and sleep disorders and noted that hyperthyroidism and hypothyroidism have clinical overlap with sleep conditions such as insomnia, restless legs syndrome, and obstructive sleep apnea. These findings highlight the importance of identifying and managing thyroid dysfunction for patients with these common sleep disorders. Additional research is needed to further understand how thyroid dysfunction affects sleep physiology.

Keywords: hyperthyroidism; hypothyroidism; insomnia; obstructive; restless legs syndrome; sleep; sleep apnea; sleep initiation and maintenance disorders.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

References

    1. Yen PM. Physiological and Molecular Basis of Thyroid Hormone Action. Physiol Rev (2001) 81(3):1097–142. 10.1152/physrev.2001.81.3.1097 - DOI - PubMed
    1. Vanderpump MP. The Epidemiology of Thyroid Disease. Br Med Bull (2011) 99:39–51. 10.1093/bmb/ldr030 - DOI - PubMed
    1. Stern RA, Robinson B, Thorner AR, Arruda JE, Prohaska ML, Prange AJ., Jr.A Survey Study of Neuropsychiatric Complaints in Patients With Graves' Disease. J Neuropsychiatry Clin Neurosci Spring (1996) 8(2):181–5. 10.1176/jnp.8.2.181 - DOI - PubMed
    1. Sridhar GR, Putcha V, Lakshmi G. Sleep in Thyrotoxicosis. Indian J Endocrinol Metab (2011) 15(1):23–6. 10.4103/2230-8210.77578 - DOI - PMC - PubMed
    1. Xia L, Chen GH, Li ZH, Jiang S, Shen J. Alterations in Hypothalamus-Pituitary-Adrenal/Thyroid Axes and Gonadotropin-Releasing Hormone in the Patients With Primary Insomnia: A Clinical Research. PloS One (2013) 8(8):e71065. 10.1371/journal.pone.0071065 - DOI - PMC - PubMed

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