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Review
. 2021 Aug 30:2021:9966738.
doi: 10.1155/2021/9966738. eCollection 2021.

Camellia sinensis in Dentistry: Technological Prospection and Scientific Evidence

Lídia Audrey Rocha Valadas  1   2 , Rosueti Diógenes de Oliveira Filho  3 , Edilson Martins Rodrigues Neto  2 , Mary Anne Medeiros Bandeira  2 , Marta Maria de França Fonteles  2 , Vanara Florêncio Passos  2 , Ana Cristina de Mello Fiallos  2 , Mara Assef Leitao Lotif  2 , Nara Juliana Custodio de Sena  2 , Thereza Cristina Farias Botelho Dantas  4   5 , Igor Lima Soares  2 , Patricia Leal Dantas Lobo  2 , Aldo Fabian Squassi  1
Affiliations
Review

Camellia sinensis in Dentistry: Technological Prospection and Scientific Evidence

Lídia Audrey Rocha Valadas et al. Evid Based Complement Alternat Med. .

Abstract

Purpose: This study aimed to evaluate reports of patents for oral care formulations, based on Camellia sinensis (C. sinensis), deposited and granted in intellectual property banks.

Methods: A survey was conducted through collection, treatment, and analysis of extracted information from patent reports selected. The documentary research was conducted in January 2021 on formulations with C. sinensis for dental applications, including since the first patent deposits until the current time. The risk of bias of clinical trials with these formulations was analyzed to verify the scientific evidence. The data extracted represent the distribution of the number of patents by banks, annual evolution of patent deposits, applicant of patents by country, distribution of patents according to International Patent Classification codes, and the types of patented products.

Results: Data and information from 20 selected patents were extracted. The United States Patent and Trademark Office (USPTO) and World Intellectual Property Organization (WIPO) were the banks with the largest number of patents for products/formulations with C. sinensis for oral care applications with 7 (35%) and 6 (30%) patent registrations, respectively. Other banks did not provide patents related to the search. Patents of compositions were the largest with 14 filings, and the remainder of formulations are represented specially by mouthwashes and toothpastes. As for clinical application, 18 patents were filed as products with antimicrobial and antibiofilm action, while 2 patents are directed to the treatment of xerostomia. In general, the aspects of the studies of clinical efficacy pointed to a low risk of bias.

Conclusion: The study pointed out a small number of products protected by patents for Camellia sinensis for oral care indication, highlighting mainly mouthwash compositions and formulations. In the methodological parameters of clinical trials carried out with the formulations, the majority pointed out a low risk of bias.

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Conflict of interest statement

The authors declare that they have no conflicts of interest.

Figures

Figure 1
Figure 1
Annual evolution number of patent filings per year with the term Camellia sinensis in formulations for oral care applications in the intellectual property banks accessed, 2021.
Figure 2
Figure 2
Applicant of patents by country with term “Camellia sinensis” in formulations for oral care applications in the intellectual property banks accessed, 2021.
Figure 3
Figure 3
Distribution of patents deposited with term “Camellia sinensis” for dental applications by International Patent Classification Codes (IPC). A61K: prescriptions for medical, dental, or hygienic purposes; A61Q: cosmetic products or formulations for personal hygiene; A61P: specific therapeutic activity of chemical compounds or medicinal presets; A01N: preservation of organisms of humans or animals or plants or their parts; A23F: coffee, tea, their substitutes, manufacture, preparation, or infusion thereof; C09K: materials for applications not otherwise provided for; applications of materials not otherwise provided for; C07D: heterocyclic compounds; Y10S: technical subjects covered by former USPC cross-reference art collections (XRACs) and digests.
Figure 4
Figure 4
Types of dental formulations deposited with the term “Camellia sinensis.” Applicant of patents by country with term “Camellia sinensis” in formulations for dental applications in the intellectual property banks accessed, 2021.
Figure 5
Figure 5
Review authors' judgements about each risk of bias item presented as percentages across all included clinical studies.
See this image and copyright information in PMC

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