Graham-Little Piccardi Lassueur syndrome and review of the literature

Abstract

Graham-Little Piccardi Lassueur Syndrome (GLPLS) is a rare variant of lichen planopilaris (LPP) which characterized by triad of fibrosing alopecia of the scalp, non-fibrosing alopecia of the axilla and groin, and a follicular spinous papule over the body. LPP is a rare follicular subtype of lichen planus which causes scarring alopecia of scalp, and there are three clinical subtypes of LPP including classic lichen planopilaris, frontal fibrosing alopecia, and GLPLS. Herein, we describe an adult dark-skinned Saudi male with GLPLS who has numerous body follicular papules, complete loss of axillary hair, and partial loss of groin hair in addition to patchy fibrosing alopecia of the scalp. To the best of our knowledge, this is the first reported case of GLPLS in Saudi Arabia.

Keywords: Graham‐Little Piccardi Lassueur syndrome; Lichen planopilaris; lichen planus; scaring alopecia.

FIGURE 1

ichthyosiform scales, follicular papules, and hair loss involving right leg

FIGURE 2

(A) diffuse scarring alopecia involving the scalp (B) dermatoscope shows peripilar cast with loss of follicular openings

FIGURE 3

Non‐scarring alopecia of right axilla also shows scattered follicular keratotic papules on the trunk which is seen in GLPL syndrome

FIGURE 4

Patchy alopecia with follicular papules involving pubic hairs

FIGURE 5

Microscopic examination of a biopsy taken from follicular papule of right leg showed orthokeratosis, hypergranulosis, acanthosis, and lichenoid infiltrate with necrotic keratinocytes (stained with hematoxylin and eosin stain H&E)