Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2021 Oct;25(10):2700-2706.
doi: 10.1007/s11605-021-05106-x. Epub 2021 Sep 9.

Enucleation of Biliary Cystadenomas: a Review

Steven M Strasberg  1 , William C Chapman  2
Affiliations
Review

Enucleation of Biliary Cystadenomas: a Review

Steven M Strasberg et al. J Gastrointest Surg. 2021 Oct.

Abstract

Background: Biliary cystadenomas are very rare benign tumors which can transform into cystadenocarcinomas. The largest case series reported on 221 cases over 30 years from 10 HPB centers, i.e., about 7 cases per center per decade. The recommended treatment is liver resection. Enucleation of biliary cystadenomas has been done rarely. The purpose of the study was to determine the outcome of enucleation of these cysts, particularly the mortality rate and the recurrence rate.

Methods: A keyword search was done using OVID followed by a search of the bibliography of papers describing the enucleation of biliary cystadenomas. Of 45 articles obtained, 25 were retained. The main reasons for exclusion were non-English language and review articles.

Results: One hundred three patients in the 25 studies were treated with enucleation. Thirteen studies described prior treatments that had failed with resulting recurrence requiring re-treatment. The main indication for enucleation was large central cysts for which liver resection would be high risk. There were no postoperative deaths in patients treated by enucleation. Thirteen studies provided long-term follow-up in 40 patients, a substantial number given the rarity of the tumor. There were no recurrences or transformations to malignancy.

Conclusions: Enucleation seems to represent a reasonable treatment technique for BCA, especially when a large cystic lesion is located centrally and/or would require a large liver resection with significant loss of parenchyma.

Keywords: Biliary cystadenoma; Biliary mucinous cystic neoplasm; Enucleation; Enucleation of hepatic cyst; Hepatic cyst; Liver cyst.

PubMed Disclaimer

References

    1. Devaney K, Goodman ZD, Ishak KG. Hepatobiliary cystadenoma and cystadenocarcinoma. A light microscopic and immunohistochemical study of 70 patients. Am J Surg Path 1994;18:1078-91. - DOI
    1. Arnaoutakis DJ, Kim Y, Pulitano C, Zaydfudim V, Squires MH, Kooby D, Groeschl R, Alexandrescu S, Bauer TW, Bloomston M, Soares K, Marques H, Gamblin TC, Popescu I, Adams R, Nagorney D, Barroso E, Maithel SK, Crawford M Sandroussi C, Marsh W, Pawlik TM. Management of biliary cystic tumors: a multi-institutional analysis of a rare liver tumor. Ann Surg 2015;261:361-7. - DOI
    1. Thomas KT, Welch D, Trueblood A, Sulur P, Wise P, Gorden DL, Chari RS, Wright Jr TK, Washington K, Pinson CW. Effective treatment of biliary cystadenoma. Ann Surg 2005;241:769-73. - DOI
    1. Vogt DP, Henderson JM, Chmielewski E. Cystadenoma and cystadenocarcinoma of the liver: a single center experience. J Am Coll Surg 2005;200:727-33. - DOI
    1. Kim JH. Pure Laparoscopic Transhepatic Enucleation of a Mucinous Cystic Neoplasm Abutting the Major Hepatic Veins at the Hepatocaval Confluence (with Video). J Gastrointest Surg 2018;22:557. - DOI

Publication types

LinkOut - more resources