Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2022 Aug;57(8):1835-1850.
doi: 10.1002/ppul.25651. Epub 2021 Sep 10.

Childhood diabetes and sleep

Alexandra D Monzon  1 , Susana R Patton  2 , Dorit Koren  3
Affiliations
Review

Childhood diabetes and sleep

Alexandra D Monzon et al. Pediatr Pulmonol. 2022 Aug.

Abstract

Sleep modulates glucose metabolism, both in healthy states and in disease. Alterations in sleep duration (insufficient and excessive) and obstructive sleep apnea may have reciprocal ties with obesity, insulin resistance and Type 2 diabetes, as demonstrated by emerging evidence in children and adolescents. Type 1 diabetes is also associated with sleep disturbances due to the influence of wide glycemic fluctuations upon sleep architecture, the need to treat nocturnal hypoglycemia, and the need for glucose monitoring and insulin delivery technologies. In this article, we provide an extensive and critical review on published pediatric literature regarding these topics, reviewing both epidemiologic and qualitative data, and provide an overview of the pathophysiology linking sleep with disorders of glucose homeostasis.

Keywords: circadian disruption; hypoglycemia; insulin resistance; obesity; obstructive sleep apnea; sleep; type 1 diabetes mellitus; type 2 diabetes mellitus.

PubMed Disclaimer

References

REFERENCES

    1. Tahmasian M, Samea F, Khazaie H, et al. The interrelation of sleep and mental and physical health is anchored in grey-matter neuroanatomy and under genetic control. Commun Biol. 2020;3(1):171.
    1. Tononi G, Cirelli C. Sleep and the price of plasticity: from synaptic and cellular homeostasis to memory consolidation and integration. Neuron. 2014;81(1):12-34.
    1. Xie L, Kang H, Xu Q, et al. Sleep drives metabolite clearance from the adult brain. Science. 2013;342(6156):373-377.
    1. Hladky SB, Barrand MA. Metabolite clearance during wakefulness and sleep. Handb Exp Pharmacol. 2019;253:385-423.
    1. Morgan D, Tsai SC. Sleep and the endocrine system. Sleep Med Clin. 2016;11(1):115-126.

LinkOut - more resources