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Comment
. 2021 Oct 11;39(10):1302-1305.
doi: 10.1016/j.ccell.2021.08.007. Epub 2021 Sep 9.

Restoring order at the cell cycle border: Co-targeting CDK4/6 and CDK2

Rinath Jeselsohn  1 , Rachel Schiff  2 , Albert Grinshpun  3
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Free article
Comment

Restoring order at the cell cycle border: Co-targeting CDK4/6 and CDK2

Rinath Jeselsohn et al. Cancer Cell. .
Free article

Abstract

Overcoming resistance to CDK4/6 inhibitors is a major clinical challenge. In this issue of Cancer Cell, Freeman-Cook et al. study mechanisms of resistance to CDK4/6 inhibitors by employing a CRISPRa screen. They identify the cyclin E-CDK2 axis and Myc signaling as key pathways of resistance and develop PF-06873600, a selective CDK2/4/6 inhibitor.

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Conflict of interest statement

Declaration of interests R.J. receives research funding from Pfizer and Lilly and is a consultant for Carrick Therapeutics and Luminex. R.S. receives research funding from AstraZeneca, GlaxoSmithKline, Puma, Biotechnology Inc., and Gilead Sciences (to the institution); she has been a past ad hoc advisory committee member for Eli Lilly; she is a consulting/advisory committee member for Macrogenics; and she has other financial interests: UpToDate Royalties.

Comment on

  • Expanding control of the tumor cell cycle with a CDK2/4/6 inhibitor.
    Freeman-Cook K, Hoffman RL, Miller N, Almaden J, Chionis J, Zhang Q, Eisele K, Liu C, Zhang C, Huser N, Nguyen L, Costa-Jones C, Niessen S, Carelli J, Lapek J, Weinrich SL, Wei P, McMillan E, Wilson E, Wang TS, McTigue M, Ferre RA, He YA, Ninkovic S, Behenna D, Tran KT, Sutton S, Nagata A, Ornelas MA, Kephart SE, Zehnder LR, Murray B, Xu M, Solowiej JE, Visswanathan R, Boras B, Looper D, Lee N, Bienkowska JR, Zhu Z, Kan Z, Ding Y, Mu XJ, Oderup C, Salek-Ardakani S, White MA, VanArsdale T, Dann SG. Freeman-Cook K, et al. Cancer Cell. 2021 Oct 11;39(10):1404-1421.e11. doi: 10.1016/j.ccell.2021.08.009. Epub 2021 Sep 13. Cancer Cell. 2021. PMID: 34520734

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