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Review
. 2021 Nov;9(11):3877-3884.
doi: 10.1016/j.jaip.2021.09.003. Epub 2021 Sep 8.

Asthma and Three Colinear Comorbidities: Obesity, OSA, and GERD

Meghan D Althoff  1 , Alexander Ghincea  2 , Lisa G Wood  3 , Fernando Holguin  1 , Sunita Sharma  4
Affiliations
Review

Asthma and Three Colinear Comorbidities: Obesity, OSA, and GERD

Meghan D Althoff et al. J Allergy Clin Immunol Pract. 2021 Nov.

Abstract

Asthma is a complex disease with heterogeneous phenotypes and endotypes that are incompletely understood. Obesity, obstructive sleep apnea, and gastroesophageal reflux disease co-occur in patients with asthma at higher rates than in those without asthma. Although these diseases share risk factors, there are some data suggesting that these comorbidities have shared inflammatory pathways, drive the development of asthma, or worsen asthma control. This review discusses the epidemiology, pathophysiology, management recommendations, and key knowledge gaps of these common comorbidities.

Keywords: Asthma; Gastroesophageal reflux disease; Obesity; Obstructive sleep apnea.

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Conflict of interest statement

Disclosure: The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

Figures

Figure 1:
Figure 1:
Relationships and proposed mechanisms between asthma, obesity, obstructive sleep apnea and gastroesophageal reflux disease
See this image and copyright information in PMC

Comment in

  • Asthma and Comorbid Conditions.
    Fuhlbrigge A, Lockey RF. Fuhlbrigge A, et al. J Allergy Clin Immunol Pract. 2021 Nov;9(11):3909-3910. doi: 10.1016/j.jaip.2021.09.007. J Allergy Clin Immunol Pract. 2021. PMID: 34749944 No abstract available.

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