doi: 10.1007/BF00401745.
Effect of mutations affecting lysyl-tRNAlys on the regulation of lysine biosynthesis in Escherichia coli
- PMID: 345082
- DOI: 10.1007/BF00401745
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Effect of mutations affecting lysyl-tRNAlys on the regulation of lysine biosynthesis in Escherichia coli
Mol Gen Genet.
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Abstract
When studying mutants affecting lysyl-tRNA synthetase or tRNAlys (hisT, hisW), a lack of correlation is clearly observed between the amount of lysyl-tRNA and the level of derepression of several lysine biosynthetic enzymes. This exlcudes the possible role of lysyl-tRNA as the specific corepressor of the lysine regulon. However, the level of derepression of DAP-decarboxylase, the last enzyme of the lysine pathway, is very low in the hisT mutant; this indicates that tRNAlys is a secondary effector involved in the regulation of the synthesis of this enzyme.
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