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Review
. 2022 Feb;71(2):424-435.
doi: 10.1136/gutjnl-2021-325428. Epub 2021 Sep 11.

What to do about the leaky gut

Michael Camilleri  1 , Adrian Vella  2
Affiliations
Review

What to do about the leaky gut

Michael Camilleri et al. Gut. 2022 Feb.
No abstract available

Keywords: dietary factors; intestinal permeability.

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Conflict of interest statement

Competing interests: MC has submitted a patent application on “Methods and materials for assessing intestinal permeability; Publication number: 20190145953” with colleagues at Mayo Clinic. AV has no conflicts of interest.

Figures

Figure 1.
Figure 1.. 12C-mannitol in urine samples collected at baseline during three test days in 60 healthy participants.
Reproduced from ref. , Khoshbin et al. Gastroenterology 2021.
Figure 2.
Figure 2.
Summary of injurious effects on intestinal barrier of fat, emulsifiers, and alcohol
See this image and copyright information in PMC

Comment in

References

    1. Camilleri M Leaky gut: mechanisms, measurement and clinical implications in humans. Gut 2019;68:1516–26. - PMC - PubMed
    1. Régnier M, Van Hul M, Knauf C, et al. Gut microbiome, endocrine control of gut barrier function and metabolic diseases. J Endocrinol 2021;248:R67–R82. - PubMed
    1. Keita AV, Söderholm JD. The intestinal barrier and its regulation by neuroimmune factors. Neurogastroenterol Motil 2010;22:718–33. - PubMed
    1. Bischoff SC, Barbara G, Buurman W, et al. Intestinal permeability – a new target for disease prevention and therapy. BMC Gastroenterol 2014;14:189. - PMC - PubMed
    1. Ghosh S, Whitley CS, Haribabu B, et al. Regulation of intestinal barrier function by microbial metabolites Cell Mol Gastroenterol Hepatol 2021;11:1463–82. - PMC - PubMed

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