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Review
. 2021 Oct;30(4):673-691.
doi: 10.1016/j.soc.2021.06.004. Epub 2021 Jul 22.

Evolution of Systemic Therapy in Metastatic Pancreatic Ductal Adenocarcinoma

Mandana Kamgar  1 , Sakti Chakrabarti  2 , Aditya Shreenivas  2 , Ben George  2
Affiliations
Review

Evolution of Systemic Therapy in Metastatic Pancreatic Ductal Adenocarcinoma

Mandana Kamgar et al. Surg Oncol Clin N Am. 2021 Oct.

Abstract

Pancreatic ductal adenocarcinoma is characterized by early systemic dissemination, a complex tumor microenvironment, as well as significant intratumoral and intertumoral heterogeneity. Treatment options and survival in pancreatic ductal adenocarcinoma have improved steadily over the last 3 decades. Although cytotoxic chemotherapy is currently the mainstay of treatment for pancreatic ductal adenocarcinoma, evolving therapeutic strategies are aimed at targeting the tumor microenvironment, metabolism, and the tumor-host immune balance.

Keywords: Adenocarcinoma of the pancreas; Chemotherapy; Evolution; Pancreatic cancer; Systemic treatment.

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Conflict of interest statement

Disclosure M. Kamgar, A. Shreenivas, S. Chakrabarti: none to disclose. B. George: Consultation for Celgene, Ipsen, Foundation Medicine, Bristol-Myer Squibb, Exelixis, Taiho Oncology, and Roche/Genentech; Research funding from Roche/Genentech, Boehringer Ingelheim, Tolero, Toray, NGM Biopharmaceuticals, Helix BioPharma, Hutchison Medipharma.

MeSH terms