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. 2021 Aug;34(3):308-312.
doi: 10.2337/ds20-0048. Epub 2021 Feb 11.

Leveraging Mechanical Forces to Target Insulin Injection-Induced Lipohypertrophy and Fibrosis

Heather E desJardins-Park  1 , Derrick C Wan  1
Affiliations

Leveraging Mechanical Forces to Target Insulin Injection-Induced Lipohypertrophy and Fibrosis

Heather E desJardins-Park et al. Diabetes Spectr. 2021 Aug.
No abstract available

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Figures

FIGURE 1
FIGURE 1
Modulating the skin mechanical environment to mitigate insulin injection site complications. A) Repeated insulin injections over time (top) can lead to two main skin sequelae: skin fibrosis, resulting from chronic injection-induced inflammation (middle row, left) and lipohypertrophy, resulting from adipocyte stimulation by insulin (middle row, right). Both of these complications contribute to impaired and inconsistent insulin uptake (bottom). B) Reduction of mechanical tension at the injection site (top), via a tension-offloading skin dressing applied to the site, could prevent injection-related skin complications. Tension offloading is known to reduce skin fibrosis after injury (middle row, left), and compressive force may reduce lipohypertrophy by preventing adipocyte expansion (middle row, right). Reduced lipohypertrophy and fibrosis would improve insulin absorption (bottom).
See this image and copyright information in PMC

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