Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2021;57(1):122.
doi: 10.1186/s41983-021-00379-0. Epub 2021 Sep 8.

Neurological sequelae of COVID-19: a review

Affiliations
Review

Neurological sequelae of COVID-19: a review

Christopher J Peterson et al. Egypt J Neurol Psychiatr Neurosurg. 2021.

Abstract

Background: The COVID-19 pandemic has produced a myriad of challenges, including identifying and treating neurological sequelae.

Main body: COVID-19 can cause olfactory and respiratory dysfunction with average recovery within 1 month and a minority of patients experiencing symptoms at 8-month follow-up. Headaches are also very common (up to 93%) amongst patients with persistent COVID-19 symptoms. COVID-19 illness may also affect cognition, although results are mixed.

Conclusion: While many studies have focused on acute COVID-19 symptoms, more longitudinal studies will need to assess the neurological sequelae of the disease. Furthermore, care must be taken when attributing sequelae to COVID-19 illness and not an unrelated cause. Finally, there is concern that COVID-19 may be associated with secondary illnesses, such as Guillain-Barre, and may even contribute to the development of diseases, such as Alzheimer's.

Keywords: COVID-19; Long term; Neurological; SARS-CoV-2; Sequelae.

PubMed Disclaimer

Conflict of interest statement

Competing interestsThe authors report no competing interests.

References

    1. Paterson RW, Brown RL, Benjamin L, Nortley R, Wiethoff S, Bharucha T, et al. The emerging spectrum of COVID-19 neurology: clinical, radiological and laboratory findings. Brain. 2020;143(10):3104–3120. doi: 10.1093/brain/awaa240. - DOI - PMC - PubMed
    1. Liguori C, Pierantozzi M, Spanetta M, Sarmati L, Cesta N, Iannetta M, et al. Subjective neurological symptoms frequently occur in patients with SARS-CoV2 infection. Brain Behav Immun. 2020;88:11–16. doi: 10.1016/j.bbi.2020.05.037. - DOI - PMC - PubMed
    1. Qin Y, Wu J, Chen T, Li J, Zhang G, Wu D, et al. Long-term microstructure and cerebral blood flow changes in patients recovered from COVID-19 without neurological manifestations. J Clin Invest. 2021 doi: 10.1172/jci147329. - DOI - PMC - PubMed
    1. Andrabi MS, Andrabi SA. Neuronal and cerebrovascular complications in coronavirus disease 2019. Front Pharmacol. 2020;11:570031. doi: 10.3389/fphar.2020.570031. - DOI - PMC - PubMed
    1. Al-Ramadan A, Rabab'h O, Shah J, Gharaibeh A. Acute and post-acute neurological complications of COVID-19. Neurol Int. 2021;13(1):102–119. doi: 10.3390/neurolint13010010. - DOI - PMC - PubMed

LinkOut - more resources