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Review
. 2021 Aug 30:14:4259-4266.
doi: 10.2147/JIR.S311640. eCollection 2021.

Insights into the Implications of Coexisting Type 2 Inflammatory Diseases

Justin P McCormick  1 , Jivianne T Lee  1
Affiliations
Review

Insights into the Implications of Coexisting Type 2 Inflammatory Diseases

Justin P McCormick et al. J Inflamm Res. .

Abstract

The role of type 2 inflammation in the pathogenesis of certain human diseases is an area of active investigation. Certain asthma, atopic dermatitis, eosinophilic esophagitis, and chronic rhinosinusitis phenotypes are characterized by a Th2 predominant inflammatory pathway and are frequently associated with comorbid conditions in patients. The purpose of this article is to review the evidence behind concurrent Th2-mediated diseases and explore how the presence of these comorbid conditions affect patient and disease outcomes.

Keywords: Th2 inflammation; asthma; atopic dermatitis; chronic rhinosinusitis; eosinophilic esophagitis; type 2 inflammation.

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Conflict of interest statement

Dr Jivianne Lee reports personal fees from Sanofi and Regeneron, outside the submitted work. The authors report no other potential conflicts of interest for this work.

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