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Review
. 2020 Sep 2;14(3):756-767.
doi: 10.1093/ckj/sfaa143. eCollection 2021 Mar.

A primer on metabolic memory: why existing diabesity treatments fail

Sidar Copur  1 , Peter Rossing  2 , Baris Afsar  3 , Alan A Sag  4 , Dimitrie Siriopol  5 , Masanari Kuwabara  6 , Alberto Ortiz  7 , Mehmet Kanbay  8
Affiliations
Review

A primer on metabolic memory: why existing diabesity treatments fail

Sidar Copur et al. Clin Kidney J. .

Abstract

Despite massive government and private sector investments into prevention of cardiovascular disease, diabetes mellitus and obesity, efforts have largely failed, and the burden of cost remains in the treatment of downstream morbidity and mortality, with overall stagnating outcomes. A new paradigm shift in the approach to these patients may explain why existing treatment strategies fail, and offer new treatment targets. This review aims to provide a clinician-centred primer on metabolic memory, defined as the sum of irreversible genetic, epigenetic, cellular and tissue-level alterations that occur with long-time exposure to metabolic derangements.

Keywords: chronic kidney disease; diabetic kidney disease; epigenetics; metabolic memory; sirtuin 1.

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Figures

FIGURE 1
FIGURE 1
Triggering factors and mechanisms of development of metabolic memory. ER, endoplasmic reticulum.
See this image and copyright information in PMC

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