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Review
. 2021 Aug 2;13(8):e16831.
doi: 10.7759/cureus.16831. eCollection 2021 Aug.

A Systematic Review of Fibrin Glue as an Ideal Treatment for the Pilonidal Disease

Myat Win  1   2 , Terry R Went  2 , Sheila W Ruo  3 , Amudhan Kannan  4   2 , Jerry Lorren Dominic  2   5   6   7 , Waleed Sultan  8   9   10 , Ketan Kantamaneni  2   11 , Vijaya Lakshmi Yanamala  2 , Anjli Tara  2   12 , Abeer O Elshaikh  13
Affiliations
Review

A Systematic Review of Fibrin Glue as an Ideal Treatment for the Pilonidal Disease

Myat Win et al. Cureus. .

Abstract

Pilonidal sinus is an acquired condition caused by irritation to the hair follicles at the natal cleft, presenting with an abscess or chronic infection. It is prevalent in young adults affecting their productive lifestyle with morbidities. There are varieties of treatment options; however, there is no consensus yet for the ideal procedure. Less invasive procedures have evolved to replace the traditional surgical techniques, which cannot significantly reduce the risks of recurrence and wound complications despite extensive surgeries. We aimed to assess the effect of fibrin glue as a primary treatment after cleaning the sinus in pilonidal sinus disease. We searched for articles from PubMed®, Ovid MEDLINE®, Ovid EMBASE®, and Cochrane CENTRAL. Six studies that included 336 patients in total were analyzed. Fibrin glue treatment in these studies reported a quicker return to normal activities postoperatively, a low rate of infection, and an acceptable rate of recurrence. Thus, fibrin glue seems beneficial in the management of pilonidal disease. However, further high-quality studies are essential to support and confirm this evidence. Future research should also evaluate its cost and implications in the ambulatory service.

Keywords: adolescent and young adults; fibrin glue; outcome measure; pilonidal sinus treatment; postoperative recovery.

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Conflict of interest statement

The authors have declared that no competing interests exist.

Figures

Figure 1
Figure 1. Mechanism of action of components included in fibrin glue
Figure 2
Figure 2. Illustration of fibrin glue application into the pilonidal wound
Figure 3
Figure 3. PRISMA flow diagram
PRISMA: Preferred Reporting Items for Systematic Reviews and Meta-Analyses [11]
See this image and copyright information in PMC

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