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Review
. 2021 Aug 24;12(8):664-674.
doi: 10.5306/wjco.v12.i8.664.

Adjuvant therapy for lung neuroendocrine neoplasms

Robert A Ramirez  1 , Katharine Thomas  2 , Aasems Jacob  3 , Karen Lin  4 , Yvette Bren-Mattison  5 , Aman Chauhan  3
Affiliations
Review

Adjuvant therapy for lung neuroendocrine neoplasms

Robert A Ramirez et al. World J Clin Oncol. .

Abstract

Pulmonary neuroendocrine neoplasms (NENs) represent a minority of lung cancers and vary from slower growing pulmonary carcinoid (PC) tumors to aggressive small cell lung cancer (SCLC). While SCLC can account for up to 15% of lung cancer, PCs are uncommon and represent about 2% of lung cancers. Surgical resection is the standard of care for early-stage PCs and should also be considered in early stage large cell neuroendocrine carcinoma (LCNEC) and SCLC. Adjuvant treatment is generally accepted for aggressive LCNEC and SCLC, however, less well established for PCs. Guidelines admit a lack of trials to support a high-level recommendation for adjuvant therapy. This manuscript will discuss the role for adjuvant therapy in NENs and review the available literature.

Keywords: Adjuvant therapy; Lung; Neuroendocrine; Pulmonary carcinoid; Small cell lung cancer.

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Conflict of interest statement

Conflict-of-interest statement: Robert A Ramirez, DO serves as a speaker for Merck & Co., Inc., Advanced Accelerator Applications, Genentech, Inc., AstraZeneca, and Ipsen Biopharmaceuticals, Inc. He is also a consultant for Curium Pharma, Advanced Accelerator Applications, AstraZeneca, Ipsen Biopharmaceuticals and Novartis Pharmaceuticals, Corp. He receives research funding from Aadi Biosciences and Merck & Co., Inc. Aman Chauhan, MD serves as an advisor for Novartis/AAA, Ipsen, Lexicon, and TerSera. He has received grants from BMS, Clovis, TerSera, Nanopharmaceuticals, EMD Serono, and ECS Progastrin. No other authors have conflicts of interest to disclose.

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