Neuroimmune Circuits Activated by Vagus Nerve Stimulation

Abstract

The interaction between the nervous system and the immune system has recently been well-recognized. Vagus nerve stimulation (VNS) presents potential as an anti-inflammatory therapy through activation of neuroimmune pathways. Detailed understanding of the neuroimmune pathways VNS evokes is critical in order to successfully use it in the clinic for the treatment of acute kidney injury, in which inflammation plays an important role. In this review, we describe recent findings regarding VNS-induced neuroimmune pathways responsible for anti-inflammation and tissue protection.

Keywords: Acute kidney injury; Neuroimmune interactions; Spleen; Sympathetic nervous system; Vagus nerve.