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. 2021 Dec;10(12):1581-1587.
doi: 10.1002/sctm.21-0239. Epub 2021 Sep 13.

A stem cell journey in ophthalmology: From the bench to the clinic

Ingrid W Caras  1 , Lila R Collins  1 , Abla A Creasey  1
Affiliations

A stem cell journey in ophthalmology: From the bench to the clinic

Ingrid W Caras et al. Stem Cells Transl Med. 2021 Dec.

Abstract

Debilitating diseases of the eye represent a large unmet medical need potentially addressable with stem cell-based approaches. Over the past decade, the California Institute for Regenerative Medicine (CIRM) has funded and supported the translation, from early research concepts to human trials, of therapeutic stem cell approaches for dry age-related macular degeneration, retinitis pigmentosa, and limbal stem cell deficiency. This article chronicles CIRM's journey in the ophthalmology field and discusses some key challenges and questions that were addressed along the way as well as questions that remain.

Keywords: cellular therapy; clinical translation; retina; retinal pigmented epithelium; stem cells.

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Conflict of interest statement

The authors declared no potential conflicts of interest.

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