Stressing out translation

Wilfredo Mellado¹, Dianna E Willis^{1

2}

Affiliations

¹ Burke Neurological Institute, White Plains, NY, USA.
² Feil Family Brain & Mind Research Institute, Weill Cornell Medicine, New York, NY, USA.

Comment

Wilfredo Mellado et al. Science. 2021.

. 2021 Sep 3;373(6559):1089-1090.

doi: 10.1126/science.abk3261. Epub 2021 Sep 1.

Wilfredo Mellado¹, Dianna E Willis^{1

2}

¹ Burke Neurological Institute, White Plains, NY, USA.
² Feil Family Brain & Mind Research Institute, Weill Cornell Medicine, New York, NY, USA.

Abstract

Integrated stress response activation drives neuropathy in Charcot-Marie-Tooth disease.

The integrated stress response contributes to tRNA synthetase-associated peripheral neuropathy.
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tRNA overexpression rescues peripheral neuropathy caused by mutations in tRNA synthetase.
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