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Review
. 2021 Dec;36(1):2010-2015.
doi: 10.1080/14756366.2021.1972994.

The possible role of methylglyoxal metabolism in cancer

Khalid O Alfarouk  1 , Saad S Alqahtani  2 , Saeed Alshahrani  3 , Jakob Morgenstern  4 , Claudiu T Supuran  5 , Stephan J Reshkin  6
Affiliations
Review

The possible role of methylglyoxal metabolism in cancer

Khalid O Alfarouk et al. J Enzyme Inhib Med Chem. 2021 Dec.

Abstract

Tumours reprogram their metabolism to acquire an evolutionary advantage over normal cells. However, not all such metabolic pathways support energy production. An example of these metabolic pathways is the Methylglyoxal (MG) one. This pathway helps maintain the redox state, and it might act as a phosphate sensor that monitors the intracellular phosphate levels. In this work, we discuss the biochemical step of the MG pathway and interrelate it with cancer.

Keywords: Methylglyoxal; cancer; enzyme; pH; redox.

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Conflict of interest statement

CT Supuran is Editor-in-Chief of Journal of Enzyme Inhibition and Medicinal Chemistry, and he was not involved in the assessment, peer review or decision-making process of this paper. The authors have no relevant affiliations of financial involvement with any organisation or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript. This includes employment, consultancies, honoraria, stock ownership or options, expert testimony, grants, or patents received or pending, or royalties.

Figures

Figure 1.
Figure 1.
Summarises the biochemical pathway of methylglyoxal metabolism.
See this image and copyright information in PMC

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