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Review
. 2021 Sep 1:2021:2626635.
doi: 10.1155/2021/2626635. eCollection 2021.

Gastrointestinal Stromal Tumor (GIST) and Synchronous Intra-Abdominal Liposarcoma: A Report of Two Rare Cases and Literature Review

Alexandros Diamantis  1 , Athina A Samara  1 , Ioannis Baloyiannis  1 , Dimitrios Symeonidis  1 , Andreas-Marios Diamantis  1 , Maria Tolia  2 , Konstantinos Bouliaris  3 , Georgios Koukoulis  4 , Konstantinos Tepetes  1
Affiliations
Review

Gastrointestinal Stromal Tumor (GIST) and Synchronous Intra-Abdominal Liposarcoma: A Report of Two Rare Cases and Literature Review

Alexandros Diamantis et al. Int J Surg Oncol. .

Abstract

Introduction: Gastrointestinal stromal tumors (GISTs) quite frequently occur synchronously with other malignancies, with most cases being adenocarcinomas. GISTs and liposarcomas are both of mesenchymal origin, and their coexistence is extremely rare.

Methods: We conducted a review of the current literature regarding the synchronous occurrence of GISTs and intra-abdominal liposarcomas. An electronic search of the literature was undertaken using MEDLINE (database provider PubMed). Furthermore, we present the first described case of an 86-year-old male with a GIST and synchronous liposarcoma, both located in the stomach, as well as a 66-year-old male with a gastric GIST and concurrent retroperitoneal liposarcoma.

Results: A total of 5 cases of synchronous GIST and intra-abdominal liposarcoma have been reported in the literature to date, with the most recent cases included in the present study.

Conclusion: Further research is required to explain any possible correlation in the coexistence of these different neoplasms of the same origin. Meanwhile, R0 resection of both tumors remains the treatment of choice.

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Conflict of interest statement

The authors declare no conflicts of interest.

Figures

Figure 1
Figure 1
The computed tomography revealed a 5.6 cm × 3.5 cm hypodense soft-tissue mass in the antrum of the stomach (white arrows).
Figure 2
Figure 2
(a) An adipocytic tumor was observed. The tumor cells showed appreciable anisocytosis and focal anisonucleosis without obvious pleomorphism. H + E, initial magnification 100x. (b) There were rare, sporadic cells with the morphologic appearance of a lipoblast. H + E, initial magnification 400x. (c) Several of the atypical adipocytes and lipoblasts showed immunoreactivity with p16 on immunohistochemistry, initial magnification 400x.
See this image and copyright information in PMC

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