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Case Reports
. 2021 Aug 15;4(3):234-238.
doi: 10.1002/agm2.12171. eCollection 2021 Sep.

Polymyalgia rheumatica as uncommon adverse event following immunization with COVID-19 vaccine: A case report and review of literature

Ciro Manzo  1 , Maria Natale  1 , Alberto Castagna  2
Affiliations
Case Reports

Polymyalgia rheumatica as uncommon adverse event following immunization with COVID-19 vaccine: A case report and review of literature

Ciro Manzo et al. Aging Med (Milton). .

Abstract

Polymyalgia rheumatica following immunization with Covid-19 mRNA vaccine: TRL-7 and TRL-9 as common link.

Keywords: ASIA syndrome; BNT162b2 vaccine; polymyalgia rheumatica.

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Conflict of interest statement

Nothing to disclose.

Figures

FIGURE 1
FIGURE 1
Tracer increased uptake is highlighted in peri‐articular and extra‐articular synovial structures of shoulder (see arrows in the right image) and pelvic girdles (see arrows in the left image)
FIGURE 2
FIGURE 2
TRL‐7, TRL‐9, mRNA vaccine, and PMR: A working‐hypothesis. PMR, polymyalgia rheumatica
See this image and copyright information in PMC

References

    1. Polack FP, Thomas SJ, Kitchin N, et al. Safety and efficacy of the BNT182b2 mRNA Covid‐19 vaccine. N Engl J Med. 2020;383:2603‐2615. 10.1056/NEJMoa2034577 - DOI - PMC - PubMed
    1. Watad A, De Marco G, Mahajna H, et al. Immune‐mediated disease flares or new‐onset disease in 27 subjects following mRNA/DNA SARS‐CoV‐2 vaccination. Vaccines. 2021;9:435. 10.3390/vaccines9050435 - DOI - PMC - PubMed
    1. González‐Gay MA, Matteson EL, Castañeda S. Polymyalgia rheumatica. Lancet. 2017;390:1700‐1712. 10.1016/S0140-6736(17)31825-1 - DOI - PubMed
    1. Manzo C, Milchert M, Natale M, Brzosko M. Polymyalgia rheumatica with normal values of both erythrocyte sedimentation rate and C‐reactive protein concentration at the time of diagnosis. Rheumatology. 2019;58:921‐923. 10.1093/rheumatology/key431 - DOI - PubMed
    1. Manzo C, Camellino D, Manzo C, Camellino D. Polymyalgia rheumatica: diagnostic and therapeutic issues of an apparently straightforward disease. Recenti Prog Med. 2017;108:221‐231. 10.1701/2695.27559 - DOI - PubMed

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