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. 2022 Apr;16(2):672-679.
doi: 10.1007/s11682-021-00540-6. Epub 2021 Sep 14.

Abnormal hippocampal substructure volume in insomnia disorder

Longmao Chen  1   2 , Ziqiang Shao  1   2 , Wangrui Lei  3 , Yan Xu  1   2 , Shuang Liu  1   2 , Min Zhang  1   2 , Shicong Wang  1   2 , Xinwen Wen  1   2 , Dahua Yu  4 , Kai Yuan  5   6   7
Affiliations

Abnormal hippocampal substructure volume in insomnia disorder

Longmao Chen et al. Brain Imaging Behav. 2022 Apr.

Abstract

To date, our understanding of the role of abnormal hippocampal volume in imaging studies of insomnia disorders (ID) has remained in apparent contradiction. Given that hippocampal function can be mapped to anatomically defined substructures, the hippocampal substructure volume can be examined in detail at present. In this study, we examined the volumes of hippocampal substructures between IDs and healthy controls (HC) to accurately find hippocampal markers of ID. First, we used the automated hippocampal substructure module in FreeSurfer6.0 to inspect T1-weighted magnetic resonance images between 22 IDs and 30 HC. Then, 12 hippocampal substructures were computed. Volumetric assessment was performed at the hippocampal substructure level between groups. Our study revealed significant reduced volume of the bilateral fimbria in IDs compared with HC (p < 0.05/12, Bonferroni corrected), although there was no difference in the total volume of hippocampus. In addition, the correlation analysis showed that the total hippocampal volume of the left hemisphere was negatively correlated with Pittsburgh Sleep Quality Index (PSQI) scores. With regard to hippocampal substructure results, negative correlations were detected between bilateral fimbria volume and clinical variables (i.e., PSQI, SDS, and SAS) in all subjects. Taken together, we revealed marked differences in the volume of the hippocampal substructure between IDs and HC, which provided a more accurate structural imaging marker for the pathological of ID.

Keywords: FreeSurfer6.0; Hippocampus; Insomnia disorder; Substructure.

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