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Review
. 2022 Mar;49(3):2055-2067.
doi: 10.1002/mp.15222. Epub 2021 Nov 7.

FLASH radiotherapy with photon beams

Pierre Montay-Gruel  1   2 , Stéphanie Corde  3   4   5 , Jean A Laissue  6 , Magdalena Bazalova-Carter  7
Affiliations
Review

FLASH radiotherapy with photon beams

Pierre Montay-Gruel et al. Med Phys. 2022 Mar.

Abstract

Ultra-high-dose rate "FLASH" radiotherapy (FLASH-RT) has been shown to drastically reduce normal tissue toxicities while being as efficacious as conventional dose rate radiotherapy to treat tumors. A large number of preclinical studies describing this so-called FLASH effect have led to the clinical translation of FLASH-RT using ultra-high-dose rate electron and proton beams. Although the vast majority of radiation therapy treatments are delivered using X-rays, few preclinical data using ultra-high-dose rate X-ray irradiation have been published. This review focuses on different methods that can be used to generate ultra-high-dose rate X-rays and their beam characteristics along with their effect on the biological tissues and the perspectives for the development of FLASH-RT with X-rays.

Keywords: FLASH-RT; X-rays; radiotherapy.

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References

REFERENCES

    1. Favaudon V, Caplier L, Monceau V, et al. Ultrahigh dose-rate FLASH irradiation increases the differential response between normal and tumor tissue in mice. Sci Transl Med. 2014;6(245):245ra93. https://doi.org/10.1126/scitranslmed.3008973
    1. Field SB, Bewley DK. Effects of dose-rate on the radiation response of rat skin. Int J Radiat Biol Relat Stud Phys Chem Med. 1974;26(3):259-267. https://doi.org/10.1080/09553007414551221
    1. Simmons DA, Lartey FM, Schüler E, et al. Reduced cognitive deficits after FLASH irradiation of whole mouse brain are associated with less hippocampal dendritic spine loss and neuroinflammation. Radiother Oncol. 2019;139:4-10. https://doi.org/10.1016/j.radonc.2019.06.006
    1. Montay-Gruel P, Acharya MM, Petersson K, et al. Long-term neurocognitive benefits of FLASH radiotherapy driven by reduced reactive oxygen species. Proc Natl Acad Sci U S A. 2019;166(22):10943-10951. https://doi.org/10.1073/pnas.1901777116
    1. Levy K, Natarajan S, Wang J, et al. Abdominal FLASH irradiation reduces radiation-induced gastrointestinal toxicity for the treatment of ovarian cancer in mice. Sci Rep. 2020;10(1):21600. https://doi.org/10.1038/s41598-020-78017-7

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